Article

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis

2022-04-16

Abstract excerpt

Osteoarthritis (OA) is an age-related joint disease with a strong and complex genetic component. Genome-wide association studies (GWAS) discovered a large number of genomic regions associated with OA. Nevertheless, to link associated genetic variants affecting the expression of OA-risk genes in relevant tissues remains a challenge. Here, we showed an unbiased approach to identify transcript single nucleotide polym...

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Literature Corpus work: 2f1a31fd-be50-547c-bcb0-d2933fb12593
DOI: 10.1101/2022.04.07.22273552

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