Article

Choice of phenotype scale is critical in biobank-based G×E tests

2026-01-21

Abstract excerpt

The importance of gene-environment interactions (G×E) for complex human traits is heavily debated. Recently, biobank-based GWAS have revealed many statistically significant G×E signals, though most lack clear evidence of biological significance. Here, we partly explain this discrepancy by showing that many G×E signals simplify to additive effects on a different phenotype scale, a classical concern that is currentl...

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Literature Corpus work: a1de9867-d657-5787-a7d2-fa97ac98cefc
DOI: 10.64898/2026.01.20.694695

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