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Article

Leveraging phenotypic variability to identify genetic interactions in human phenotypes.

American journal of human genetics - 7 Jan 2021

Marderstein Andrew R, Davenport Emily R, Kulm Scott, Van Hout Cristopher V, Elemento Olivier, Clark Andrew G

Abstract excerpt

Although thousands of loci have been associated with human phenotypes, the role of gene-environment (GxE) interactions in determining individual risk of human diseases remains unclear. This is partly because of the severe erosion of statistical power resulting from the massive number of statistical tests required to detect such interactions. Here, we focus on improving the power of GxE tests by developing a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33326753
DOI: 10.1016/j.ajhg.2020.11.016
PMCID: PMC7820920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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