Article

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy

2021-01-06

Abstract excerpt

The D301N NLRP3 mutation in mice (D303N in humans) causes severe multi-organ damage and early death driven by the constitutively activated NLRP3 (NLRP3 ca ) inflammasome. Triggered inflammasomes activate caspase-1 to process IL-1 family cytokines and gasdermin D (GSDMD), generating N-terminal fragments, which oligomerize within the plasma membrane to form pores, which cause inflammatory cell death (pyroptosis) an...

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Literature Corpus work: a1bdb413-8ec9-5a06-a461-f04463f0adbd
DOI: 10.1101/2021.01.06.425634

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