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Article

IL-1β drives SARS-CoV-2-induced disease independently of the inflammasome and pyroptosis signalling

27 Feb 2025

Abstract excerpt

Abstract Excessive inflammation and cytokine release are hallmarks of severe COVID-19. Certain programmed cell death processes can drive inflammation, however, their role in the pathogenesis of severe COVID-19 is unclear. Pyroptosis is a pro-inflammatory form of regulated cell death initiated by inflammasomes and executed by the pore-forming protein gasdermin D (GSDMD). Using an established mouse adapted...

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PMID: 40016339
DOI: 10.1038/s41418-025-01459-x

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