Article
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2016
Aglietti Robin A, Estevez Alberto, Gupta Aaron, Ramirez Monica Gonzalez, Liu Peter S, Kayagaki Nobuhiko, Ciferri Claudio, Dixit Vishva M, Dueber Erin C
Abstract excerpt
Gasdermin-D (GsdmD) is a critical mediator of innate immune defense because its cleavage by the inflammatory caspases 1, 4, 5, and 11 yields an N-terminal p30 fragment that induces pyroptosis, a death program important for the elimination of intracellular bacteria. Precisely how GsdmD p30 triggers pyroptosis has not been established. Here we show that human GsdmD p30 forms functional pores within membranes. When...
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