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Article

Gasdermin D mutation protects against renal ischemia reperfusion injury.

Physiological reports - 1 Apr 2025

Li Jennifer S Y, Moudgil Aadhar, Meijles Daniel N, Shaw Karli, Julovi Sohel M, Trinh Katie, Alexander Stephen I, Rogers Natasha M

Abstract excerpt

Pyroptosis, the most inflammatory form of cell death, is dependent on membrane pore formation governed by the assembly of cleaved Gasdermin D (GSDMD). We hypothesized that regulated necrosis pathways are crucial in the pathophysiology of acute kidney injury (AKI). Mice with an isoleucine-to-asparagine loss-of-function mutation in the Gasdermin D gene (GSDMDI105N/I105N) generated by ethylnitrosourea-mutagenesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40268886
DOI: 10.14814/phy2.70254
PMCID: PMC12018169

Genes

GSDMD

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Gasdermin D mutation protects against renal ischemia reperfusion injury.PMID 40268886Read ↗

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