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Article

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.

Structure (London, England : 1993) - 1 May 2018

Liu Zhonghua, Wang Chuanping, Rathkey Joseph K, Yang Jie, Dubyak George R, Abbott Derek W, Xiao Tsan Sam

Abstract excerpt

Pyroptosis is an inflammatory form of programmed cell death that plays important roles in immune protection against infections and in inflammatory disorders. Gasdermin D (GSDMD) is an executor of pyroptosis upon cleavage by caspases-1/4/5/11 following canonical and noncanonical inflammasome activation. GSDMD N-terminal domain assembles membrane pores to induce cytolysis, whereas its C-terminal domain inhibits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29576317
DOI: 10.1016/j.str.2018.03.002
PMCID: PMC5932255

Genes

GSDMD
GSDMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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