Article

Gasdermin D mediates inflammation-induced defects in reverse cholesterol transport and promotes atherosclerosis

2021-04-16

Abstract excerpt

Activation of inflammasomes, such as Nlrp3 and Aim2, can exacerbate atherosclerosis in mice and humans. Gasdermin D (GsdmD) serves as a final executor of inflammasome activity, by generating membrane pores for the release of mature Interleukin-1beta (IL-1β). Inflammation dampens reverse cholesterol transport (RCT) and promotes atherogenesis, while anti-IL-1β antibodies were shown to reduce cardiovascular disease i...

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Literature Corpus work: 1d87529f-83b4-55e4-bd74-7dd5e31d33ab
DOI: 10.1101/2021.04.16.440183

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