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Activation and Regulation of NLRP3 by Sterile and Infectious Insults

12 May 2022

Abstract excerpt

Nod-Like Receptor (NLR) is the largest family of Pathogen Recognition Receptors (PRRs) that patrols the cytosolic environment. NLR engagement drives caspase-1 activation that cleaves pro-IL-1B which then gets secreted. Released IL-1B recruits immune cells to the site of infection/injury. Caspase-1 also cleaves Gasdermin-D (GSDM-D) that forms pores within the plasma membrane driving inflammatory cell death called...

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PMID: 35663964
DOI: 10.3389/fimmu.2022.896353

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