Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gasdermins and their role in immunity and inflammation

23 Sept 2019

Abstract excerpt

The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic cell death that is induced upon formation of caspase-1-activating inflammasomes. The related proteins GSDME and GSDMA have also been implicated in autoimmune diseases and certain cancers....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune and Inflammatory Disorders Research
Share to IL-33, ST2, and ILC Pathways
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31548300
DOI: 10.1084/jem.20190545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gasdermins and their role in immunity and inflammationPMID 31548300Read ↗

Emerging insights on the role of gasdermins in infection and inflammatory diseasesSemantic proximity Read ↗

Pyroptosis, inflammasome, and gasdermins in tumor immunitySemantic proximity Read ↗

The role of pyroptosis in inflammatory diseasesSemantic proximity Read ↗

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.Semantic proximity Read ↗

Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseasesSemantic proximity Read ↗

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.Semantic proximity Read ↗

Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic PotentialSemantic proximity Read ↗

The Versatile Gasdermin Family: Their Function and Roles in DiseasesSemantic proximity Read ↗

Gasdermin E: A Prospective Target for Therapy of DiseasesSemantic proximity Read ↗

The regulation of pyroptosis by post-translational modifications: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid ArthritisSemantic proximity Read ↗

Pyroptosis, metabolism, and tumor immune microenvironmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.