Article
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Nature - 29 Oct 2015
Kayagaki Nobuhiko, Stowe Irma B, Lee Bettina L, O'Rourke Karen, Anderson Keith, Warming Søren, Cuellar Trinna, Haley Benjamin, Roose-Girma Merone, Phung Qui T, Liu Peter S, Lill Jennie R, Li Hong, Wu Jiansheng, Kummerfeld Sarah, Zhang Juan, Lee Wyne P, Snipas Scott J, Salvesen Guy S, Morris Lucy X, Fitzgerald Linda, Zhang Yafei, Bertram Edward M, Goodnow Christopher C, Dixit Vishva M
Abstract excerpt
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1β processing, and lethal septic shock. How caspase-11 executes these downstream signalling events is largely unknown. Here we show that gasdermin D is essential for...
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