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Article

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.

Nature - 7 Jul 2016

Liu Xing, Zhang Zhibin, Ruan Jianbin, Pan Youdong, Magupalli Venkat Giri, Wu Hao, Lieberman Judy

Abstract excerpt

Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and human gasdermin D (GSDMD) after Asp276 and Asp275, respectively, to generate an N-terminal cleavage product (GSDMD-NT) that triggers inflammatory death (pyroptosis) and release of inflammatory cytokines such as interleukin-1β. Cleavage removes the C-terminal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27383986
DOI: 10.1038/nature18629
PMCID: PMC5539988

Genes

GSDMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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