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Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases

17 Oct 2019

Abstract excerpt

Pyroptosis is a form of necrotic and inflammatory programmed cell death, which could be characterized by cell swelling, pore formation on plasma membranes, and release of proinflammatory cytokines (IL-1β and IL-18). The process of pyroptosis presents as dual effects: protecting multicellular organisms from microbial infection and endogenous dangers; leading to pathological inflammation if overactivated. Two...

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PMID: 31621910
DOI: 10.1002/jcp.29268

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