Article

Simeprevir Improves Osteoarthritis Cartilage Degeneration and Inflammation by Targeting PRPS2 to Inhibit Purine Metabolism and NF-κB Signaling Pathway

2026-06-04

Abstract excerpt

<title>Abstract</title> <p>Background The progression of osteoarthritis (OA) is increasingly recognized as being driven by metabolic-inflammatory crosstalk. Phosphoribosyl pyrophosphate synthetase 2 (PRPS2), a crucial rate-limiting enzyme in purine synthesis, exhibits unique pathogenic potential in cellular metabolic reprogramming. This study aimed to elucidate the specific pathological role of PRPS2 in OA and e...

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Literature Corpus work: 138a2c76-7af7-5d90-9754-41425d937e6f
DOI: 10.21203/rs.3.rs-9768783/v1

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