Article

ALPK1 regulates Synovitis in the Temporomandibular Joint via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization

2023-01-10

Abstract excerpt

ALPK1 (Alpha-kinase 1) was shown to be expressed on macrophages and associated with a variety of inflammatory diseases. The goal of this study was to clarify whether ALPK1 activation influences macrophage polarization, inducing inflammatory cytokine release and then contributes to synovial inflammation of TMJ. This study demonstrated that ALPK1 was highly upregulated not only in the synovial fluid of patients with...

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Literature Corpus work: 54069a7d-13f7-56b5-8e50-17558d1ad038
DOI: 10.21203/rs.3.rs-2408682/v1

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