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Article

Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients

23 Jan 2019

Abstract excerpt

Osteoarthritis (OA) is a leading cause of disability, globally. Despite an emerging role for synovial inflammation in OA pathogenesis, attempts to target inflammation therapeutically have had limited success. A better understanding of the cellular and molecular processes occurring in the OA synovium is needed to develop novel therapeutics. We investigated macrophage phenotype and gene expression in synovial...

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PMID: 30674730
DOI: 10.1172/jci.insight.125325

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