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Article

MSMP promotes an aberrant phenotype of fibroblast-like synoviocytes in rheumatoid arthritis by blocking autophagy via the RUNX1/GPR137B axis.

Arthritis research & therapy - 3 Feb 2026

Wang Cuicui, Zeng Yanting, Tan Peiyao, Yuan Shiwen, Li Weinian, Ye Jinghua, Chen Ming, Lao Minxi, Xiao Youjun, Liang Liuqin, Xu Hanshi, Cai Xiaoyan

Abstract excerpt

BACKGROUND: Microseminoprotein (MSMP) is a secreted protein that has been identified as a novel ligand for C-C chemokine receptor 2 (CCR2), despite lacking the classical chemokine structure. Emerging evidence suggests that MSMP is implicated in the progression of various cancers and inflammatory diseases. However, its role in rheumatoid arthritis (RA) remains unknown. The study aims to investigate the regulatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41629965
DOI: 10.1186/s13075-026-03755-4
PMCID: PMC12954899

Genes

MSMP
GPR137B
RUNX1
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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