Article
Macrophages regulate the progression of osteoarthritis.
Osteoarthritis and cartilage - 1 May 2020
Zhang H, Cai D, Bai X
Abstract excerpt
OA is now well accepted as a low-grade inflammatory disease affecting the whole joint. In addition to mechanical loading, inflammation (particularly synovitis), contributes significantly to OA. Synovial macrophages act as immune cells and are of critical importance in the symptomology and structural progression of OA. Activated macrophages are regulated by mTOR, NF-κB, JNK, PI3K/Akt and other signaling pathways,...
Topics
Join the communities discussing this publication.