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Article

A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis

5 Sept 2014

Abstract excerpt

Growth Arrest-Specific 5 (GAS5) is known to negatively regulate cell survival and is aberrantly expressed in several cancers. The influence of GAS5 on osteoarthritis (OA) has not been determined. To address this, articular chondrocytes were isolated from relatively normal (Non-OA) and clear OA regions (OA) of cartilage in total knee replacement (TKR) patients and biopsied normal cartilage. We found that GAS5 was...

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PMID: 25196583
DOI: 10.1002/jor.22718

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