Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate

doi:10.1111/cpr.12998

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Article

Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate

1 Feb 2021

Abstract excerpt

Growth differentiation factor 5 (GDF-5) is essential for cartilage development and homeostasis. The expression and function of GDF-5 are highly associated with the pathogenesis of osteoarthritis (OA). OA, characterized by progressive degeneration of joint, particularly in cartilage, causes severe social burden. However, there is no effective approach to reverse the progression of this disease. Over the past...

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Inflammatory mediators and NSAID effects
Osteoarthritis Treatment and Mechanisms
TGF-β signaling in diseases

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PMID: 33522652
DOI: 10.1111/cpr.12998

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