Article

Therapeutically expanded human regulatory T-cells are super- suppressive due to HIF1A induced expression of CD73.

2020-11-20

Abstract excerpt

<title>Abstract</title> <p>The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolis...

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Literature Corpus work: 623f2505-a824-5d6e-ae9a-675df11a9ca6
DOI: 10.21203/rs.3.rs-92789/v1

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