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Article

The Inhibitory Effect of Adenosine on Tumor Adaptive Immunity and Intervention Strategies

2023-07-03

Abstract excerpt

Adenosine (Ado), mainly produced by the hydrolysis of ATP, exhibits significantly elevated levels in the tumor microenvironment (TME) compared to normal tissues. Upon binding to adenosine receptors (AdoRs), Ado initiates downstream signaling pathways that suppress tumor antigen presentation and immune cell activation, thereby inhibiting tumor adaptive immunity. Ado downregulates major histocompatibility complex II...

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Literature Corpus work
84e1f126-2d49-51f3-8936-0ab79f9348fe
DOI
10.22541/au.168838779.94228226/v1
Open publication

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