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Article

Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward

1 Oct 2021

Abstract excerpt

Tumors accumulate metabolites that deactivate infiltrating immune cells and polarize them toward anti-inflammatory phenotypes. We provide a comprehensive review of the complex networks orchestrated by several of the most potent immunosuppressive metabolites, highlighting the impact of adenosine, kynurenines, prostaglandin E2, and norepinephrine and epinephrine, while discussing completed and ongoing clinical...

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PMID: 34667078
DOI: 10.1136/jitc-2021-003013

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