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Article

Compromised paraspeckle formation as a pathogenic factor in FUSopathies

11 Dec 2013

Abstract excerpt

Paraspeckles are nuclear bodies formed by a set of specialized proteins assembled on the long non-coding RNA NEAT1; they have a role in nuclear retention of hyperedited transcripts and are associated with response to cellular stress. Fused in sarcoma (FUS) protein, linked to a number of neurodegenerative disorders, is an essential paraspeckle component. We have shown that its recruitment to these nuclear...

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PMID: 24334610
DOI: 10.1093/hmg/ddt622

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Compromised paraspeckle formation as a pathogenic factor in FUSopathiesPMID 24334610Read ↗

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