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Cellular NONO protein binds to the flavivirus replication complex and promotes positive-strand RNA synthesis

5 Nov 2024

Abstract excerpt

A cellular protein, non-POU-domain-containing octamer binding protein (NONO), bound to the replication complex of Japanese encephalitis virus (JEV) by directly interacting with the viral 3' UTR RNA and NS3 protein. These interactions were also identified in West Nile virus (WNV) and Zika virus (ZIKV). The infection of JEV or the expression of JEV NS3 protein in cells could induce relocation of NONO protein from...

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HIV Research and Treatment
Mosquito-borne diseases and control
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39499073
DOI: 10.1128/jvi.00297-24

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