Article
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation.
Molecular cell - 6 Aug 2020
Wang Chen, Duan Yongjia, Duan Gang, Wang Qiangqiang, Zhang Kai, Deng Xue, Qian Beituo, Gu Jinge, Ma Zhiwei, Zhang Shuang, Guo Lin, Liu Cong, Fang Yanshan
Abstract excerpt
Despite the prominent role of TDP-43 in neurodegeneration, its physiological and pathological functions are not fully understood. Here, we report an unexpected role of TDP-43 in the formation of dynamic, reversible, liquid droplet-like nuclear bodies (NBs) in response to stress. Formation of NBs alleviates TDP-43-mediated cytotoxicity in mammalian cells and fly neurons. Super-resolution microscopy reveals...
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