Article

SIGIRR Deficiency Contributes to CD4 T Cell Abnormalities by Facilitating the IL1/C/EBPβ/TNF-α Signaling Axis in Rheumatoid Arthritis

2022-04-12

Abstract excerpt

<title>Abstract</title> Rheumatoid arthritis (RA) is a complex autoimmune disease with multiple etiological factors, among which aberrant T-cell activation plays a key role in the initiation and perpetuation of the disease. The factors that trigger T cell abnormalities in these inflammatory processes are incompletely understood. SIGIRR (single immunoglobulin IL-1R-related receptor) is a member of the IL-1 rece...

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Literature Corpus work: a15adc54-2191-5158-bbd0-a6406b469695
DOI: 10.21203/rs.3.rs-1490835/v1

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