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Article

Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis.

The Journal of pathology - 1 Apr 2010

Lech Maciej, Skuginna Veronika, Kulkarni Onkar P, Gong Jing, Wei Tiandi, Stark Robert W, Garlanda Cecilia, Mantovani Alberto, Anders Hans-Joachim

Abstract excerpt

Multiple genetic factors contribute to the clinical variability of spontaneous systemic lupus erythematosus (SLE) but their role in drug-induced SLE remain largely unknown. Hydrocarbon oil-induced SLE depends on mesothelial cell apoptosis and Toll-like receptor (TLR)-7-mediated induction of type I interferons. Hence, we hypothesized that TIR8/SIGIRR, an endogenous TLR inhibitor, prevents oil-induced SLE....

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Topics

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Share to Antibodies, Antinuclear
Share to Ascitic Fluid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lupus Nephritis

Share to Myeloid Differentiation Factor 88

Share to Receptors, Interleukin-1

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Source

Identifiers

PMID: 20112371
DOI: 10.1002/path.2678

Genes

SIGIRR
TLR7
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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