Article

Seven chain adaptive immune receptor repertoire analysis in rheumatoid arthritis: association to disease and clinically relevant phenotypes

2021-11-28

Abstract excerpt

<h4>ABSTRACT</h4> Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease characterized by a defective adaptive immune receptor repertoire (AIRR) that fails to distinguish self from non-self antigens. The AIRR is vast, encompassing four T cell receptor (TCR) and three B cell receptor (BCR) chains, each of which displays an extraordinary amino acid sequence variability in the antigen-binding site. How...

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Literature Corpus work: 93d83a2a-a426-5c22-a452-8ff43694e0e6
DOI: 10.1101/2021.11.26.21266347

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