Article

SIRPγ modulates effector differentiation of human CD8 T Cells under suboptimal TCR stimulation: implications for immune homeostasis and autoimmunity

2025-07-14

Abstract excerpt

<h4>Background</h4> Aberrant CD8 T-cell differentiation contributes to the pathogenesis of autoimmune diseases, and immune-mediated tissue damage. However, the molecular mechanisms that prevent premature effector T cell programming in humans remain incompletely defined. Signal regulatory protein gamma (SIRPγ) is selectively expressed on T-cells in the human immune system. Notably, genetic variants associated with...

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Literature Corpus work: ff1b8d5f-98c4-5650-99d7-1ba5587ce26d
DOI: 10.1101/2025.07.09.663913

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