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Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators

1 Oct 2018

Abstract excerpt

The immune system is highly diverse, but characterization of its genetic architecture has lagged behind the vast progress made by genome-wide association studies (GWASs) of emergent diseases. Our GWAS for 54 functionally relevant phenotypes of the adaptive immune system in 489 healthy individuals identifies eight genome-wide significant associations explaining 6%-20% of variance. Coding and splicing variants in...

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PMID: 30332657
DOI: 10.1016/j.celrep.2018.09.048

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