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Human KIR <sup>+</sup> CD8 <sup>+</sup> T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19

2021-12-25

Abstract excerpt

Previous reports show that Ly49 + CD8 + T cells can suppress autoimmunity in mouse models of autoimmune diseases. Here we find a markedly increased frequency of CD8 + T cells expressing inhibitory Killer cell Immunoglobulin like Receptors (KIR), the human equivalent of the Ly49 family, in the blood and inflamed tissues of various autoimmune diseases. Moreover, KIR + CD8 + T cells can efficiently eliminate pat...

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Identifiers and source

Literature Corpus work
e65ce087-e97b-5791-b4c0-967eb4220ab7
DOI
10.1101/2021.12.23.473930
Open publication

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Human KIR <sup>+</sup> CD8 <sup>+</sup> T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19DOI 10.1101/2021.12.23.473930
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