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Article

A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases

1 Jan 2011

Abstract excerpt

IL-1 cytokine family plays a key role in the innate immune response against pathogen- and danger-associated molecular patterns. More recently, IL-1 receptor type 1 (IL-R1) signaling has been identified as a critical step in the differentiation and commitment of Th17 cells, which mediate the development of autoimmune diseases. Given its significance in the induction of the adoptive immune response, this complex...

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PMID: 21776333
DOI: 10.4161/self.2.1.15639

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