Article

Identification of drugs for leukaemia differentiation therapy by network pharmacology

2019-07-05

Abstract excerpt

Acute leukaemias differ from their normal haematopoietic counterparts in their inability to differentiate. This phenomenon is thought to be the result of aberrant cellular reprogramming involving transcription factors (TFs). Here we leveraged on Mogrify, a network-based algorithm, to identify TFs and their gene regulatory networks that drive differentiation of the acute promyelocytic leukaemia (APL) cell line NB4...

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Literature Corpus work: a13bfca8-215f-540b-a337-fa6e085bb080
DOI: 10.1101/676106

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