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Article

Large-Scale Elucidation of Drug Response Pathways in Humans

1 Feb 2012

Abstract excerpt

Elucidating signaling pathways is a fundamental step in understanding cellular processes and developing new therapeutic strategies. Here we introduce a method for the large-scale elucidation of signaling pathways involved in cellular response to drugs. Combining drug targets, drug response expression profiles, and the human physical interaction network, we infer 99 human drug response pathways and study their...

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PMID: 22300318
DOI: 10.1089/cmb.2011.0264

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