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Article

Cell line-specific gene network enrichment analysis for interpreting continuous phenotypes.

Briefings in bioinformatics - 4 May 2026

Park Heewon, Imoto Seiya, Miyano Satoru

Abstract excerpt

Gene network enrichment analysis (GNEA) offers a robust approach for interpreting the complex molecular mechanisms underlying phenotypic variability. Despite its utility, prevailing GNEA methodologies are predominantly optimized for binary phenotypes, leading to substantial information loss when applied to continuous biological traits such as drug sensitivity, cancer progression, etc. Additionally, traditional...

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Identifiers

PMID: 42531063
DOI: 10.1093/bib/bbag413
PMCID: PMC13435233

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BTK
MS4A1
PTPN11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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