Article

Epigenome-Based Drug Repositioning in Acute Myeloid Leukemia

2017-06-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Repositioning approved drugs for the treatment of new indications is a promising avenue to reduce the burden of drug development. Most currently available computational methods based on molecular evidence can only utilize gene expression for repositioning despite a growing interest in the epigenome in human disease. We recently described a novel repositioning method, ksRepo,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dee12ef0-3f4f-5940-a855-de9ddd8cba62
DOI: 10.1101/152157

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenome-Based Drug Repositioning in Acute Myeloid LeukemiaDOI 10.1101/152157Read

Combining clinical and molecular data for personalized treatment in acute myeloid leukemia: A machine learning approach.Semantic proximity Read

Machine Learning for Predicting Therapeutic Outcomes in Acute Myeloid Leukemia PatientsSemantic proximity Read

Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimenSemantic proximity Read

Identification of drugs for leukaemia differentiation therapy by network pharmacologySemantic proximity Read

Predicting gene expression changes upon epigenomic drug treatmentSemantic proximity Read

Predicting gene expression changes upon epigenomic drug treatmentSemantic proximity Read

Prediction of drug targets for specific diseases leveraging gene perturbation data: A machine learning approachSemantic proximity Read

Transcriptional data: a new gateway to drug repositioning?Semantic proximity Read

A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study.Semantic proximity Read

DNA methylation and personalized medicine.Semantic proximity Read

Sparse expression bases in cancer reveal tumor drivers.Semantic proximity Read

Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature.Semantic proximity Read