Article

Comparative Transcriptomic Analysis of ATRA-Resistant and ATRA-Sensitive APL Cell Lines Identifies lncRNA Biomarkers Associated with Drug Resistance

2026-01-30

Abstract excerpt

Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia characterized by the t(15;17) translocation, leading to the PML (Promyelocytic leukemia protein ) -RARA (Retinoic Acid Receptor Alpha) fusion protein. Although PML-RARA fusion is common, there are 20 more fusion events also reported in APL. All -trans retinoic acid (ATRA) is a standard drug for APL, leading to significant improvement in...

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Literature Corpus work: 89dfa9dc-e4ab-5b15-81f7-165e8b0838cc
DOI: 10.64898/2026.01.27.702191

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