Article

Systems Pharmacology Reveals Type I Interferon and Myeloid-Like B Cell Reprogramming as Druggable Axes in Antiphospholipid Syndrome

2026-04-30

Abstract excerpt

Antiphospholipid syndrome (APS) lacks targeted therapies beyond anticoagulation, and its molecular heterogeneity remains poorly characterized. We employed an integrative systems pharmacology approach combining weighted gene co-expression network analysis (WGCNA), single-cell RNA sequencing, Connectivity Map (CMap) screening, and molecular docking to identify druggable targets in APS. WGCNA of bulk RNA-seq data fro...

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Literature Corpus work: a1e2776e-3552-5ba7-ae0f-538d7fa300df
DOI: 10.64898/2026.04.28.721277

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