Back to search

Article

In Silico Analysis of Aberrant Gene Expression Profiles in Haematologic Malignancies and their Impact on Mismatch Repair Functions 

2022-04-28

Abstract excerpt

<h4>Background: </h4> - The tissue microenvironment in cancers involves complex network of biomolecular interactions. Differentially expressed genes (DEGs) in diseased conditions have crucial role in cancer diagnosis. Here, we mined expression profiles (Affymetrix microarray datasets) of six different haematologic malignancies from Gene Expression Omnibus (GEO). We filtered the common DEGs across all the six profi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e1692810-200b-5c9b-a4d2-b6ccf4016af0
DOI
10.21203/rs.3.rs-1577715/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
In Silico Analysis of Aberrant Gene Expression Profiles in Haematologic Malignancies and their Impact on Mismatch Repair FunctionsDOI 10.21203/rs.3.rs-1577715/v1
Deregulation of MMR-Related Pathways and Anticancer Potential of Curcuma Derivatives– A Computational ApproachSemantic proximity
Construction and evaluation of a prognostic risk model of DNA mismatch repair related genes in colorectal cancerSemantic proximity
Chemogenomics Mapping of Potential Drugs and Targets for Treatment of Multiple MyelomaSemantic proximity
A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancerSemantic proximity
Multiomics analysis of homologous recombination deficiency across cancer types.Semantic proximity
Analysis of the differential expression and prognostic relationship of DEGs in AML based on TCGA databaseSemantic proximity
Identification of Novel Genes Implicated in Acute Myeloid Leukemia Progression using Bioinformatics Analysis of Microarray DataSemantic proximity
Screen and evaluate the prognostic capacity and clinical value of Necroptosis-related Genes in acute myeloid leukemiaSemantic proximity
Exploring the differentially expressed genes in human lymphocytes upon response to ionizing radiation: a network biology approachSemantic proximity
Pancancer analysis of DNA damage repair gene mutations and their impact on immune regulatory gene expressionSemantic proximity
Identification of aberrantly methylated-differentially expressed genes and potential agents for Ewing’s sarcomaSemantic proximity
Bioinformatics Analysis Identifies Key Genes and Pathways in Acute Myeloid Leukemia Associated with DNMT3A Mutation.Semantic proximity
Select a neighboring publication to make it the new centre.