Article

Phenotypic analysis of an MLL-AF4 gene regulatory network reveals indirect CASP9 repression as a mode of inducing apoptosis resistance

2020-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Regulatory interactions mediated by transcription factors (TFs) make up complex networks that control cellular behavior. Fully understanding these gene regulatory networks (GRNs) offers greater insight into the consequences of disease-causing perturbations than studying single TF binding events in isolation. Chromosomal translocations of the Mixed Lineage Leukemia gene ( MLL ) produce MLL fusi...

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Literature Corpus work: 8a4dc4b4-6e60-59e4-8c47-76a72887304b
DOI: 10.1101/2020.06.30.179796

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