Article

PathBone-MF: A lineage-aware interpretable virtual bone cell model for structure-only prediction of drug bone effects

2026-08-25

Abstract excerpt

<b>Background and Purpose</b>: Bone metabolic diseases remain a major public health burden, partly because predicting whether a drug promotes, inhibits, or is unrelated to bone formation is difficult before wet-lab testing. Existing perturbation-prediction methods target pan-cancer scenarios, lack bone-lineage specificity, and are largely black boxes. We aimed to build PathBone-MF, an interpretable virtual bone ce...

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Literature Corpus work: 05a69e8b-8262-5cc2-a239-251cbc9c850d
DOI: 10.22541/authorea.15007847/v1

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