Article

How Aberrant <i>N</i> -Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic View

2022-12-22

Abstract excerpt

Protein assembly defects due to enrichment of aberrant conformational variants of proteins are emerging as a new frontier in therapeutics design. Understanding, atomistically, structural elements that remodel the energy landscape of proteins, with the consequence of rewiring the conformational dynamics of proteins and pathologically perturbing functionally-oriented ensembles, is key for development of inhibitors....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0f04629-bfe7-58b7-902c-3b83dacaa95d
DOI: 10.1101/2022.12.22.521543

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

How Aberrant <i>N</i> -Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic ViewDOI 10.1101/2022.12.22.521543Read

Protein Dynamics at Different Timescales Unlock Access to Hidden Post-Translational Modification SitesSemantic proximity Read

Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern.Semantic proximity Read

How and why plants and human N-glycans are different: Insight from molecular dynamics into the “glycoblocks” architecture of complex carbohydratesSemantic proximity Read

Mathematical modelling of mutant glycoprotein fate in the ERSemantic proximity Read

Deciphering molecular determinants of GPCR-G protein receptor interactions by complementary integrative structural biology methodsSemantic proximity Read

Disease-related single-point mutations alter the global dynamics of a tetratricopeptide (TPR) a-solenoid domainSemantic proximity Read

Evolution of Protein Regulation in the Vertebrate Glucose SensorSemantic proximity Read

Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts.Semantic proximity Read

Functional and structural impact of the most prevalent missense mutations in classic galactosemiaSemantic proximity Read

Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT.Semantic proximity Read

SlytheRINs: using graph parameters and residue interaction networks to analyze protein dynamics and structural ensemblesSemantic proximity Read

Interaction networks within disease-associated GαS variants characterized by an integrative biophysical approach.Semantic proximity Read