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Mathematical modelling of mutant glycoprotein fate in the ER

2025-12-02

Abstract excerpt

<h4>Background</h4> The endoplasmic reticulum (ER) coordinates glycoprotein quality control through competing pathways: ER quality control (ERQC) and ER-associated degradation (ERAD). The fate of a glycoprotein is tied to its N -glycan(s) structure, which serves as a “molecular barcode” for quality control. In particular, modulation of ERQC/ERAD can increase leakage of responsive ( i.e ., non-inactive) glycopro...

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Literature Corpus work
2e3b276a-b2b4-5932-8c33-8033f5545bd3
DOI
10.64898/2025.11.30.691435
Open publication

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Mathematical modelling of mutant glycoprotein fate in the ERDOI 10.64898/2025.11.30.691435
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