Back to search

Article

Evolution of Protein Regulation in the Vertebrate Glucose Sensor

2026-05-07

Abstract excerpt

Protein regulation is essential for cellular function and mis-regulation commonly causes disease. Despite this fact, we know little about how new regulatory strategies first emerge and how they evolve to act in concert to control complex physiological processes. Glucokinase (GCK), the body’s glucose sensor, lies at the heart of vertebrate glucose homeostasis and its activity is tightly controlled by multiple regul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
096dbe77-55ba-5040-93ab-98ad24b3a5a6
DOI
10.64898/2026.05.05.723016
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Evolution of Protein Regulation in the Vertebrate Glucose SensorDOI 10.64898/2026.05.05.723016
Dual allosteric activation mechanisms in monomeric human glucokinase.Semantic proximity
Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease.Semantic proximity
Characterizing glucokinase variant mechanisms using a multiplexed abundance assaySemantic proximity
The Role of Conformational Dynamics and Allostery in Modulating Protein Evolution.Semantic proximity
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.Semantic proximity
Determinants of human glucokinase activation and implications for small molecule allosteric control.Semantic proximity
Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycationSemantic proximity
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.Semantic proximity
Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycationSemantic proximity
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.Semantic proximity
Aiding Cancer’s “Sweet Tooth”: Role of Hexokinases in Metabolic ReprogrammingSemantic proximity
Hexokinase domain-containing protein-1 in metabolic diseases and beyondSemantic proximity
Select a neighboring publication to make it the new centre.