Article

Disease-related single-point mutations alter the global dynamics of a tetratricopeptide (TPR) a-solenoid domain

2019-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Tetratricopeptide repeat (TPR) proteins belong to the class of α-solenoid proteins, in which repetitive units of α-helical hairpin motifs stack to form superhelical, often highly flexible structures. TPR domains occur in a wide variety of proteins, and perform key functional roles including protein folding, protein trafficking, cell cycle control and post-translational modification. Here, we loo...

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Literature Corpus work: 4f56fb62-3015-5d71-bd34-8e86a8f3c55d
DOI: 10.1101/598672

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