Article

Protein Dynamics at Different Timescales Unlock Access to Hidden Post-Translational Modification Sites

2025-06-27

Abstract excerpt

<h4>Summary</h4> Post-translational modifications (PTMs) alter the proteome in response to intra- and extracellular signals, providing fundamental information processing in development, homeostasis and disease 1–5 . Here, we used proteome-wide structure predictions to investigate the structural context of protein modification sites and found nearly a fifth to be buried within proteins 6 . These cryptic sites wi...

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Literature Corpus work: 2872f12e-f95a-5ca1-86a2-4eaae146f922
DOI: 10.1101/2025.06.25.661537

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