Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern.

Abstract excerpt

Glycosylation of the SARS-CoV-2 spike (S) protein represents a key target for viral evolution because it affects both viral evasion and fitness. Successful variations in the glycan shield are difficult to achieve though, as protein glycosylation is also critical to folding and structural stability. Within this framework, the identification of glycosylation sites that are structurally dispensable can provide...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to COVID-19
• Share to Glycosylation
• Share to Molecular Dynamics Simulation