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Article

Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT.

Nature communications - 11 Nov 2021

Meek Richard W, Blaza James N, Busmann Jil A, Alteen Matthew G, Vocadlo David J, Davies Gideon J

Abstract excerpt

The O-linked β-N-acetylglucosamine modification is a core signalling mechanism, with erroneous patterns leading to cancer and neurodegeneration. Although thousands of proteins are subject to this modification, only a single essential glycosyltransferase catalyses its installation, the O-GlcNAc transferase, OGT. Previous studies have provided truncated structures of OGT through X-ray crystallography, but the...

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PMID: 34764280
DOI: 10.1038/s41467-021-26796-6
PMCID: PMC8586251

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